Meningococcal Type IV Pili Recruit the Polarity Complex to Open the Cell-Cell Junctions of Brain Endothelium
نویسندگان
چکیده
1 Université Paris Descartes, Faculté de Médecine, INSERM (U-570), Paris, France. 2 Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France. 3 INSERM, U567, Paris, France. 4 INSERM UMR-S 839, Université Pierre et Marie Curie-Paris6, Institut du Fer à Moulin, Paris, France. 5 AP-HP, Hôpital Necker-Enfants Malades, Paris, F-75015, France. 6 Weill Cornell Medical College, New York, USA. 7 Department of Life Sciences, The Open University, Walton Hall, Milton Keynes, UK. 8 Present address: INSERM U970, Paris Cardiovascular Research Center, Paris, F-75015, France
منابع مشابه
Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium.
Type IV pili mediate the initial interaction of many bacterial pathogens with their host cells. In Neisseria meningitidis, the causative agent of cerebrospinal meningitis, type IV pili-mediated adhesion to brain endothelial cells is required for bacteria to cross the blood-brain barrier. Here, type IV pili-mediated adhesion of N. meningitidis to human brain endothelial cells was found to recrui...
متن کاملTwo strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells.
Following adhesion on brain microvasculature, Neisseria meningitidis is able to cross the blood-brain barrier (BBB) by recruiting the polarity complex and the cell junction proteins, thus allowing the opening of the paracellular route. This feature is the consequence of the activation by the type IV pili of the β2-adrenergic receptor/β-arrestin signaling pathway. Here, we have extended this obs...
متن کاملThe meningococcal minor pilin PilX is responsible for type IV pilus conformational changes associated with signaling to endothelial cells.
Neisseria meningitidis crosses the blood-brain barrier (BBB) following the activation of the β2-adrenergic receptor by the type IV pili (TFP). Two components of the type IV pili recruit the β2-adrenergic receptor, the major pilin PilE and the minor pilin PilV. Here, we report that a strain deleted of PilX, one of the three minor pilins, is defective in endothelial cell signaling. The signaling ...
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UNLABELLED Type IV pili (Tfp) are expressed by many Gram-negative bacteria to promote aggregation, adhesion, internalization, twitching motility, or natural transformation. Tfp of Neisseria meningitidis, the causative agent of cerebrospinal meningitis, are involved in the colonization of human nasopharynx. After invasion of the bloodstream, Tfp allow adhesion of N. meningitidis to human endothe...
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